Research Output 1997 2017

2017

A-kinase anchoring protein 79/150 scaffolds transient receptor potential a 1 phosphorylation and sensitization by metabotropic glutamate receptor activation

Brackley, A. D., Gomez, R., Guerrero, K. A., Akopian, A. N., Glucksman, M. J., Du, J., Carlton, S. M. & Jeske, N. A. Dec 1 2017 In : Scientific Reports. 7, 1, 1842

Research output: Research - peer-reviewArticle

Metabotropic Glutamate Receptors
Protein Kinases
Hypersensitivity
Phosphorylation
Sensory Receptor Cells

Comparative Evaluation of Chemotactic Factor Effect on Migration and Differentiation of Stem Cells of the Apical Papilla

Fayazi, S., Takimoto, K. & Diogenes, A. Aug 1 2017 In : Journal of Endodontics. 43, 8, p. 1288-1293 6 p.

Research output: Research - peer-reviewArticle

Chemotactic Factors
Stem Cells
Granulocyte Colony-Stimulating Factor
Endodontics
Fibroblast Growth Factor 2
1 Citations

Decellularized Human Dental Pulp as a Scaffold for Regenerative Endodontics

Song, J. S., Takimoto, K., Jeon, M., Vadakekalam, J., Ruparel, N. B. & Diogenes, A. Jun 1 2017 In : Journal of Dental Research. 96, 6, p. 640-646 7 p.

Research output: Research - peer-reviewArticle

Dental Pulp
Endodontics
Tooth
Stem Cells
Dental Pulp Cavity
1 Citations

Effect of Bacterial Biofilm on the Osteogenic Differentiation of Stem Cells of Apical Papilla

Vishwanat, L., Duong, R., Takimoto, K., Phillips, L., Espitia, C. O., Diogenes, A., Ruparel, S. B., Kolodrubetz, D. & Ruparel, N. B. Jun 1 2017 In : Journal of Endodontics. 43, 6, p. 916-922 7 p.

Research output: Research - peer-reviewArticle

Biofilms
Stem Cells
Enterococcus faecalis
Endodontics
Dental Pulp Cavity
Dental Pulp
Hydrogel
Hyaluronic Acid
Regeneration
Injections

Evaluation of mesenchymal stem cell modulation of trigeminal neuronal responses to cold

Eskander, M. A., Takimoto, K. & Diogenes, A. Sep 30 2017 In : Neuroscience. 360, p. 61-67 7 p.

Research output: Research - peer-reviewArticle

Mesenchymal Stromal Cells
Stem Cells
Coculture Techniques
Endodontics
Neurons
1 Citations

Extracellular matrix-derived hydrogels for dental stem cell delivery

Viswanath, A., Vanacker, J., Germain, L., Leprince, J. G., Diogenes, A., Shakesheff, K. M., White, L. J. & des Rieux, A. Jan 1 2017 In : Journal of Biomedical Materials Research - Part A. 105, 1, p. 319-328 10 p.

Research output: Research - peer-reviewArticle

Hydrogels
Extracellular Matrix
Tooth
Stem Cells
Stem cells
1 Citations

Histologic Evaluation of Regenerative Endodontic Procedures with the Use of Chitosan Scaffolds in Immature Dog Teeth with Apical Periodontitis

Palma, P. J., Ramos, J. C., Martins, J. B., Diogenes, A., Figueiredo, M. H., Ferreira, P., Viegas, C. & Santos, J. M. Aug 1 2017 In : Journal of Endodontics. 43, 8, p. 1279-1287 9 p.

Research output: Research - peer-reviewArticle

Periapical Periodontitis
Endodontics
Chitosan
Tooth
Dogs
Endodontics
Stem Cells
Direction compound
Dental Pulp Cavity
Dentin
1 Citations

Regenerative Endodontic Procedures: Clinical Outcomes

Diogenes, A. & Ruparel, N. B. Jan 1 2017 In : Dental Clinics of North America. 61, 1, p. 111-125 15 p.

Research output: Research - peer-reviewReview article

Endodontics
Dentin
Dental Pulp Necrosis
Tooth
Research
1 Citations

Survival of the Apical Papilla and Its Resident Stem Cells in a Case of Advanced Pulpal Necrosis and Apical Periodontitis

Chrepa, V., Pitcher, B., Henry, M. A. & Diogenes, A. Apr 1 2017 In : Journal of Endodontics. 43, 4, p. 561-567 7 p.

Research output: Research - peer-reviewArticle

Periapical Periodontitis
Necrosis
Stem Cells
Survival
Tooth
2016
1 Citations

Adding Regenerative Endodontics to the Table of Contents

Hargreaves, K. M. Jan 1 2016 In : Journal of Endodontics. 42, 1, p. 1 1 p.

Research output: Research - peer-reviewArticle

2 Citations

BDNF signaling contributes to oral cancer pain in a preclinical orthotopic rodent model

Chodroff, L., Bendele, M., Valenzuela, V., Henry, M. & Ruparel, S. Sep 1 2016 In : Molecular Pain. 12

Research output: Research - peer-reviewArticle

Mouth Neoplasms
Brain-Derived Neurotrophic Factor
Rodentia
Pain
Cancer Pain

Capsaicin-sensitive Innervation Modulates the Development of Apical Periodontitis

Austah, O. N., Ruparel, N. B., Henry, M. A., Fajardo, R. J., Schmitz, J. E. & Diogenes, A. Oct 1 2016 In : Journal of Endodontics. 42, 10, p. 1496-1502 7 p.

Research output: Research - peer-reviewArticle

Periapical Periodontitis
Capsaicin
Neurons
Calcitonin Gene-Related Peptide
Dental Pulp
4 Citations
Hyperalgesia
Lipids
Wounds and Injuries
Spinal Cord
Pain

Clinical strategies for dental and periodontal disease management: A way forward

Diogenes, A., Chrepa, V. & Ruparel, N. B. Nov 1 2016 Tissue Engineering and Regeneration in Dentistry: Current Strategies. Wiley Blackwell, p. 145-168 24 p.

Research output: ResearchChapter

Stomatognathic Diseases
Periodontal Diseases
Disease Management
Therapeutics
Regeneration

EphrinB2 Stabilizes Vascularlike Structures Generated by Endothelial Cells and Stem Cells from Apical Papilla

Yuan, C., Wang, P., Zhu, S., Zou, T., Wang, S., Xu, J., Heng, B. C., Diogenes, A. & Zhang, C. 2016 (Accepted/In press) In : Journal of Endodontics.

Research output: Research - peer-reviewArticle

Human Umbilical Vein Endothelial Cells
Stem Cells
Endothelial Cells
Coculture Techniques
Phosphorylation
3 Citations

GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity

Brackley, A. D., Gomez, R., Akopian, A. N., Henry, M. A. & Jeske, N. A. Sep 1 2016 In : Cell Reports. 16, 10, p. 2686-2698 13 p.

Research output: Research - peer-reviewArticle

G-Protein-Coupled Receptor Kinase 2
delta Opioid Receptor
Opioid Analgesics
Analgesics
raf Kinases
1 Citations

Influence of Age and Apical Diameter on the Success of Endodontic Regeneration Procedures

Estefan, B. S., El Batouty, K. M., Nagy, M. M. & Diogenes, A. Nov 1 2016 In : Journal of Endodontics. 42, 11, p. 1620-1625 6 p.

Research output: Research - peer-reviewArticle

Endodontics
Regeneration
Tooth
Age Groups
Incisor
1 Citations

Oscillating from Neurosecretion to Multitasking Dopamine Neurons

Grattan, D. R. & Akopian, A. N. Apr 26 2016 In : Cell Reports. 15, 4, p. 681-682 2 p.

Research output: Research - peer-reviewArticle

Neurosecretion
Dopaminergic Neurons
Neurons
Multitasking
Dopamine
3 Citations

Role of Oxidized Lipids and TRP Channels in Orofacial Pain and Inflammation

Dubner, R., Hargreaves, K. M. & Ruparel, S. Sep 1 2016 In : Journal of Dental Research. 95, 10, p. 1117-1123 7 p.

Research output: Research - peer-reviewReview article

Facial Pain
Linoleic Acid
Inflammation
Lipids
vanilloid receptor subtype 1
1 Citations

The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1

Bertin, S., Aoki-Nonaka, Y., Lee, J., de Jong, P. R., Kim, P., Han, T., Yu, T., To, K., Takahashi, N., Boland, B. S., Chang, J. T., Ho, S. B., Herdman, S., Corr, M., Franco, A., Sharma, S., Dong, H., Akopian, A. N. & Raz, E. Jun 20 2016 (Accepted/In press) In : Gut.

Research output: Research - peer-reviewArticle

Ankyrins
Colitis
Ion Channels
T-Lymphocytes
vanilloid receptor subtype 1
3 Citations

TRP channels and traffic-related environmental pollution-induced pulmonary disease

Akopian, A. N., Fanick, E. R. & Brooks, E. G. May 1 2016 In : Seminars in Immunopathology. 38, 3, p. 331-338 8 p.

Research output: Research - peer-reviewArticle

Transient Receptor Potential Channels
Vehicle Emissions
Environmental Pollution
Lung Diseases
Particulate Matter
2015

Advances in the dental and surgical management of orofacial pain

Palla, S., Hargreaves, K. M., Winocur, E. & Palla, A. Jun 1 2015 Orofacial Pain. Wolters Kluwer Health Adis (ESP)

Research output: ResearchChapter

Stomatognathic System
Facial Pain
Tooth
Pain
Referred Pain
21 Citations

Delivery of apical mesenchymal stem cells into root canals of mature teeth

Chrepa, V., Henry, M. A., Daniel, B. J. & Diogenes, A. Dec 1 2015 In : Journal of Dental Research. 94, 12, p. 1653-1659 7 p.

Research output: Research - peer-reviewArticle

Dental Pulp Cavity
Mesenchymal Stromal Cells
Tooth
Hemorrhage
Endodontics
12 Citations

Dental apical papilla as therapy for spinal cord injury

De Berdt, P., Vanacker, J., Ucakar, B., Elens, L., Diogenes, A., Leprince, J. G., Deumens, R. & Des Rieux, A. Nov 1 2015 In : Journal of Dental Research. 94, 11, p. 1575-1581 7 p.

Research output: Research - peer-reviewArticle

Dental Papilla
Spinal Cord Injuries
Therapeutics
Stem Cells
Hydrogel
4 Citations

Effect of a novel, orally active matrix metalloproteinase-2 and -9 inhibitor in spinal and trigeminal rat models of neuropathic pain

Henry, M. A., Fairchild, D. D., Patil, M. J., Hanania, T., Hain, H. S., Davis, S. F., Malekiani, S. A., Hu, A., Sucholeiki, R., Nix, D. & Sucholeiki, I. 2015 In : Journal of Oral and Facial Pain and Headache. 29, 3, p. 286-296 11 p.

Research output: Research - peer-reviewArticle

Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Neuralgia
AQU-118
gabapentin
7 Citations

Fibrin hydrogels to deliver dental stem cells of the apical papilla for regenerative medicine

Germain, L., De Berdt, P., Vanacker, J., Leprince, J., Diogenes, A., Jacobs, D., Vandermeulen, G., Bouzin, C., Préat, V., Dupont-Gillain, C. & Des Rieux, A. Mar 1 2015 In : Regenerative Medicine. 10, 2, p. 153-167 15 p.

Research output: Research - peer-reviewArticle

Hydrogels
Regenerative Medicine
Fibrin
Tooth
Stem Cells
Facial Pain
Pain
Cancer Pain
Animal Models
Theoretical Models
10 Citations

In Vitro Analysis of Scaffold-free Prevascularized Microtissue Spheroids Containing Human Dental Pulp Cells and Endothelial Cells

Dissanayaka, W. L., Zhu, L., Hargreaves, K. M., Jin, L. & Zhang, C. May 1 2015 In : Journal of Endodontics. 41, 5, p. 663-670 8 p.

Research output: Research - peer-reviewArticle

Dental Pulp
Endothelial Cells
In Vitro Techniques
Human Umbilical Vein Endothelial Cells
Extracellular Matrix

Men with acute cholecystitis have higher tissue-based cytokine levels than women: A cross-sectional study

Fehrenbacher, J. C., Bingener, J., Aho, J. M., Wasky, P. R., Locke, E. E., Schwesinger, W. H., Van Sickle, K. R. & Hargreaves, K. M. Apr 1 2015 In : Chirurgia (Turin). 28, 2, p. 49-53 5 p.

Research output: Research - peer-reviewArticle

Acute Cholecystitis
Cross-Sectional Studies
Cytokines
Gallbladder
Extracellular Fluid
26 Citations

Persistent nociception triggered by nerve growth factor (NGF) is mediated by TRPV1 and oxidative mechanisms

Eskander, M. A., Ruparel, S., Green, D. P., Chen, P. B., Por, E. D., Jeske, N. A., Gao, X., Flores, E. R. & Hargreaves, K. M. Jun 3 2015 In : Journal of Neuroscience. 35, 22, p. 8593-8603 11 p.

Research output: Research - peer-reviewArticle

Nociception
Nerve Growth Factor
vanilloid receptor subtype 1
Hyperalgesia
Capsaicin
5 Citations

Released lipids regulate Transient Receptor Potential Channel (TRP)-dependent oral cancer pain

Ruparel, S., Bendele, M., Wallace, A. & Green, D. May 26 2015 In : Molecular Pain. 11, 1, 30

Research output: Research - peer-reviewArticle

Transient Receptor Potential Channels
Mouth Neoplasms
Lipids
Cancer Pain
Hyperalgesia
1 Citations

Role of TRP ion channels in physiology and pathology introduction

Akopian, A. Nov 12 2015 (Accepted/In press) In : Seminars in Immunopathology.

Research output: Research - peer-reviewArticle

8 Citations

Temporal-controlled Dexamethasone Releasing Chitosan Nanoparticle System Enhances Odontogenic Differentiation of Stem Cells from Apical Papilla

Shrestha, S., Diogenes, A. & Kishen, A. Aug 1 2015 In : Journal of Endodontics. 41, 8, p. 1253-1258 6 p.

Research output: Research - peer-reviewArticle

Chitosan
Nanoparticles
Dexamethasone
Stem Cells
Odontoblasts
27 Citations

The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo

Dissanayaka, W. L., Hargreaves, K. M., Jin, L., Samaranayake, L. P. & Zhang, C. Feb 1 2015 In : Tissue Engineering - Part A. 21, 3-4, p. 550-563 14 p.

Research output: Research - peer-reviewArticle

Dental Pulp
Hydrogel
Regeneration
Stem Cells
Endothelial Cells
2014
5 Citations
Estrogen Receptor alpha
Bradykinin
Sensory Receptor Cells
Nociception
Estrogen Receptors
10 Citations

A standardized novel method to measure radiographic root changes after endodontic therapy in immature teeth

Flake, N. M., Gibbs, J. L., Diogenes, A., Hargreaves, K. M. & Khan, A. A. Jan 2014 In : Journal of Endodontics. 40, 1, p. 46-50 5 p.

Research output: Research - peer-reviewArticle

Endodontics
Tooth
Therapeutics
Tooth Root
Outcome Assessment (Health Care)
50 Citations

Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla survival and differentiation

Martin, D. E., De Almeida, J. F. A., Henry, M. A., Khaing, Z. Z., Schmidt, C. E., Teixeira, F. B. & Diogenes, A. Jan 2014 In : Journal of Endodontics. 40, 1, p. 51-55 5 p.

Research output: Research - peer-reviewArticle

Sodium Hypochlorite
Stem Cells
Survival
dentin sialophosphoprotein
Edetic Acid
3 Citations

Direct effect of endodontic sealers on trigeminal neuronal activity

Ruparel, N. B., Ruparel, S. B., Chen, P. B., Ishikawa, B. & Diogenes, A. 2014 In : Journal of Endodontics. 40, 5, p. 683-687 5 p.

Research output: Research - peer-reviewArticle

Calcitonin Gene-Related Peptide
Endodontics
Zinc Oxide
Eugenol
Nociceptors
41 Citations

Effect of dentin conditioning with intracanal medicaments on survival of stem cells of apical papilla

Althumairy, R. I., Teixeira, F. B. & Diogenes, A. 2014 In : Journal of Endodontics. 40, 4, p. 521-525 5 p.

Research output: Research - peer-reviewArticle

Dentin
Ointments
Stem Cells
Anti-Bacterial Agents
Survival
44 Citations

Evaluation of triple antibiotic paste removal by different irrigation procedures

Berkhoff, J. A., Chen, P. B., Teixeira, F. B. & Diogenes, A. 2014 In : Journal of Endodontics. 40, 8, p. 1172-1177 6 p.

Research output: Research - peer-reviewArticle

Ointments
Anti-Bacterial Agents
Dentin
Dental Pulp Cavity
Calcium Hydroxide
19 Citations

Hypoxia modulates the differentiation potential of stem cells of the apical papilla

Vanacker, J., Viswanath, A., De Berdt, P., Everard, A., Cani, P. D., Bouzin, C., Feron, O., Diogenes, A., Leprince, J. G. & des Rieux, A. Sep 1 2014 In : Journal of endodontics. 40, 9, p. 1410-1418 9 p.

Research output: Research - peer-reviewArticle

Stem Cells
Hypoxia
Up-Regulation
Vascular Endothelial Growth Factor B
Neurotrophin 3
6 Citations
Translational Medical Research
Endodontics
Clinical Protocols
Research Personnel
Outcome Assessment (Health Care)
9 Citations

Prolactin receptor in regulation of neuronal excitability and channels

Patil, M. J., Henry, M. A. & Akopian, A. N. 2014 In : Channels. 8, 3, p. 193-202 10 p.

Research output: Research - peer-reviewArticle

Prolactin Receptors
Prolactin
Neurons
Maternal Behavior
Neurogenesis

Pulp Injury and Changing Trends in Treatment

Hargreaves, K. M., Diogenes, A. & Teixeira, F. B. Nov 13 2014 Stem Cell Biology and Tissue Engineering in Dental Sciences. Elsevier Inc., p. 397-404 8 p.

Research output: ResearchChapter

Tooth
Wounds and Injuries
Canals
Tissue engineering
Pulp
15 Citations

Scaffold-free prevascularized microtissue spheroids for pulp regeneration

Dissanayaka, W. L., Zhu, L., Hargreaves, K. M., Jin, L. & Zhang, C. Dec 25 2014 In : Journal of Dental Research. 93, 12, p. 1296-1303 8 p.

Research output: Research - peer-reviewArticle

Tooth Root
Regeneration
Dental Pulp
Human Umbilical Vein Endothelial Cells
Extracellular Matrix
11 Citations

Stem cells of the apical papilla regulate trigeminal neurite outgrowth and targeting through a BDNF-dependent mechanism

De Almeida, J. F. A., Chen, P., Henry, M. A. & Diogenes, A. Dec 1 2014 In : Tissue Engineering - Part A. 20, 23-24, p. 3089-3100 12 p.

Research output: Research - peer-reviewArticle

Brain-Derived Neurotrophic Factor
Stem Cells
Neuronal Outgrowth
Stem cells
Brain
13 Citations
Chitosan
Bovine Serum Albumin
Nanoparticles
Alkaline Phosphatase
Stem Cells
27 Citations

The Effect of Photodynamic Therapy in Root Canal Disinfection: A Systematic Review

Chrepa, V., Kotsakis, G. A., Pagonis, T. C. & Hargreaves, K. M. 2014 In : Journal of Endodontics. 40, 7, p. 891-898 8 p.

Research output: Research - peer-reviewArticle

Dental Pulp Cavity
Disinfection
Photochemotherapy
Bacterial Load
Meta-Analysis